Variation between specialist uropatholgists in reporting extraprostatic extension after radical prostatectomy - Abstract

AIMS: Extraprostatic extension of prostate cancer in radical prostatectomy specimens significantly affects patient management.

We evaluated the degree of interobserver variation between uropathologists at a tertiary referral teaching hospital in assessing the extraprostatic extension of prostate cancer in radical prostatectomy specimens.

METHODS: Histopathological data from a consecutive series of 293 radical prostatectomy specimens (January 2007-December 2012) were reviewed. A subset of 50 consecutive radical prostatectomy cases originally staged as tumours confined to the prostate (pT2) or tumours extending into periprostatic tissue (pT3a) during this period were reviewed by four specialist uropathologists.

RESULTS: Five consultant histopathologists reported these specimens with significant differences in the reported stage (p=0.0164) between pathologists. Double-blind review by 4 uropathologists of 50 consecutive radical prostatectomy cases showed a lack of consensus in 16/50 (32%) cases (κ score 0.58, moderate agreement). A consensus meeting was held, but consensus could still not be reached in 9/16 cases.

CONCLUSIONS: Our findings highlight variability in the reporting of pT stage in radical prostatectomy specimens even by specialist uropathologists. Assessment of extraprostatic extension has important implications for patient management and there is a need for more precise guidance.

Written by:
Bryant RJ, Schmitt AJ, Roberts IS, Gill PS, Browning L, Brewster SF, Hamdy FC, Verrill C.   Are you the author?
Nuffield Department of Surgical Sciences, University of Oxford, Old Road Campus Research Building (off Roosevelt Drive), Oxford, UK; Department of Urology, Oxford University Hospitals NHS Trust, Churchill Hospital, Oxford, UK; Department of Cellular Pathology, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Oxford, UK.

Reference: J Clin Pathol. 2015 Mar 19. pii: jclinpath-2014-202661.
doi: 10.1136/jclinpath-2014-202661

PubMed Abstract
PMID: 25792751 Prostate Cancer Section


Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.