Information of prostate biopsy positive core: Does it affect MR detection of prostate cancer on using 3T-MRI? - Abstract

OBJECTIVE: We assessed which information from a prostate biopsy had the strongest relationship with prostate cancer detection by 3T-MRI.

MATERIALS AND METHODS: Sixty-one consecutive patients with biopsy-proven prostate cancer who underwent 3T-MRI before biopsy were enrolled in this retrospective study. Two radiologists independently reviewed T2-weighted and diffusion-weighted images. When the cancer lesions were revealed by biopsy and MRI depicted them at corresponding sites, we classified these lesions as MRI-detectable cancer. If the cancer lesions were revealed by biopsy, but any cancers had not been detected, we classified these lesions as MRI-undetectable cancer. We compared the Gleason score (GS), cancer ratio (CaR) and cancer length (CaL) from core biopsies between the two groups.

THE RESULTS: GS, CaR and CaL differed significantly between the MRI-detectable group (N = 70), and the MRI-undetectable group (N = 73). 3T-MRI could detect cancer cores with a sensitivity of 90.5 % in cores with CaR ≥ 60 %, and with a sensitivity of 81.8 % in those with CaL ≥ 5 mm. Receiver operating characteristic analysis showed that CaR (P = 0.006) and CaL (P = 0.010) significantly associated with the prostate cancer detection using MRI rather than GS.

CONCLUSION: CaR and CaL from the core biopsies showed a stronger relationship to detection of the prostate cancer on 3T-MRI than the GS did.

Written by:
Yoshida R, Kaji Y, Tamaki Y, Katsube T, Kitagaki H, Kanbara T, Kamai T.   Are you the author?
Department of Radiology, Faculty of Medicine, Shimane University, 89-1, Enya-cho, Izumo, Shimane, 693-8501, Japan.

Reference: Jpn J Radiol. 2015 Mar 12. Epub ahead of print.
doi: 10.1007/s11604-015-0407-4

PubMed Abstract
PMID: 25761402 Prostate Cancer Section