Is primary tumor detectable in prostatic carcinoma at routine contrast-enhanced CT? - Abstract

OBJECTIVES: To determine if prostatic carcinoma (PCa) is detectable at routine contrast-enhanced CT (CECT).

MATERIALS AND METHODS: With institutional review board approval, 63 consecutive PCa patients underwent CECT before therapy. Two blinded radiologists assessed for rounded focal enhancing peripheral zone nodules. Diagnostic accuracy and inter-observer agreement were compared by Gleason Score (GS).

RESULTS: Overall sensitivity was 63-76% with moderate agreement, K=0.42. The false-positive rate was 15%. Sensitivities and agreement for GS 9-10, 7-8 and 6 PCa were 84-91%, 73-84%, 41-71%, (P=.023 and .001) and K=(0.72, 0.69, 0.23).

CONCLUSIONS: CECT has good sensitivity for detecting GS ≥7 PCa with substantial agreement and a low false-positive rate.

Written by:
Schieda N, Al-Dandan O, Shabana W, Flood TA, Malone SC.   Are you the author?
The Ottawa Hospital, The University of Ottawa, 1053 Carling Avenue, Ottawa, Ontario, Canada K1Y 4E9; The Ottawa Hospital, The University of Ottawa, Department of Radiology, Civic Campus C1, 1053 Carling Avenue; Ottawa, Ontario, Canada, K1Y 4E9; The Ottawa Hospital, The University of Ottawa, Department of Anatomical Pathology, 501 Smyth Road, 4th floor CCW, Room 4278; Ottawa, Ontario, Canada, K1Y 4E9; The Ottawa Hospital, The University of Ottawa, Department of Radiation Oncology, 501 Smyth Road, Cancer Care Wing; Ottawa, Ontario, Canada, K1Y 4E9. ; ; ; ;

Reference: Clin Imaging. 2015 Jan 16. pii: S0899-7071(15)00010-8.
doi: 10.1016/j.clinimag.2015.01.008


PubMed Abstract
PMID: 25682301

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