Multiparametric-MRI and targeted biopsies in the management of prostate cancer patients on active surveillance - Abstract

An important key to clinical management of prostate cancer patients is to determine early those who will benefit from primary treatment and are not good candidates for active surveillance (AS).

We describe a 67-year-old gentleman with a long history of stable prostate-specific antigen (PSA) levels and a negative biopsy. After slight PSA rise and low volume Gleason score 6 biopsy, the patient was considered for primary treatment or AS. A multiparametric (MP)-MRI exam revealed a suspicious lesion in the anterior apex of the prostate. Biopsies were carried out on a 3D-ultrasound prostate biopsy system with MRI-fusion. The location of the target area was challenging and could have been missed using standard 12-core biopsy template. The pathology determined Gleason 3 + 4 disease in 30% of the core from this region. Consequently, the patient underwent radiotherapy (RT). MP-MRI was also used to follow the changes from pre- to post-RT.

Written by:
Sandler K, Patel M, Lynne C, Parekh DJ, Punnen S, Jorda M, Casillas J, Pollack A, Stoyanova R.   Are you the author?
Department of Radiation Oncology, University of Miami, Miami, FL, USA; Department of Urology, University of Miami, Miami, FL, USA; Department of Pathology, University of Miami, Miami, FL, USA; Department of Radiology, University of Miami, Miami, FL, USA.

Reference: Front Oncol. 2015 Jan 26;5:4.
doi: 10.3389/fonc.2015.00004

PubMed Abstract
PMID: 25674540 Prostate Cancer Section


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