INTRODUCTION: The association between Lynch syndrome and prostate cancer has been studied.
Recent studies report an association between these two diseases.
MATERIAL AND METHODS: Literature review based on PubMed search was performed using the following keywords: Lynch syndrome and prostate cancer.
RESULTS: Eight articles analyzing cohorts of subjects carrying Lynch syndrome were analysed including 6786 patients with 175 cancers. Prostate cancers were more frequent with a standardized incidence ratio (SIR) from 0.93 (95% CI: 0.19-2.7) and 5.9 (95% CI 4.1-17.1) and occurs at a younger age than in the general population mainly for mutations in the MSH2 gene.
CONCLUSION: Prostate cancer seem more frequent and occur earlier in individuals harboring a mutation in the MSH2 gene while it does not appear to be any difference compared to the general population for other mutations in Lynch syndrome.
Maillard F, Manouvrier S, Biardeau X, Ouzzane A, Villers A. Are you the author?
Service d'urologie, hôpital Claude-Huriez, CHRU de Lille, 1, place de Verdun, 59037 Lille cedex, France; Service de génétique clinique, hôpital Jeanne-de-Flandre, avenue Eugène-Avinee, 59037 Lille, France; Faculté de médecine H.-Warembourg, université de Lille II, avenue Eugène-Avinée, 59045 Lille cedex, France; Faculté de médecine H.-Warembourg, université de Lille II, avenue Eugène-Avinée, 59045 Lille cedex, France. ; ; ; ;
Reference: Prog Urol. 2015 Jan 29. pii: S1166-7087(15)00002-0.
Article in French.