Lynch syndrome and risk of prostate cancer; review of the literature - Abstract

INTRODUCTION: The association between Lynch syndrome and prostate cancer has been studied.

Recent studies report an association between these two diseases.

MATERIAL AND METHODS: Literature review based on PubMed search was performed using the following keywords: Lynch syndrome and prostate cancer.

RESULTS: Eight articles analyzing cohorts of subjects carrying Lynch syndrome were analysed including 6786 patients with 175 cancers. Prostate cancers were more frequent with a standardized incidence ratio (SIR) from 0.93 (95% CI: 0.19-2.7) and 5.9 (95% CI 4.1-17.1) and occurs at a younger age than in the general population mainly for mutations in the MSH2 gene.

CONCLUSION: Prostate cancer seem more frequent and occur earlier in individuals harboring a mutation in the MSH2 gene while it does not appear to be any difference compared to the general population for other mutations in Lynch syndrome.

Written by:
Maillard F, Manouvrier S, Biardeau X, Ouzzane A, Villers A.   Are you the author?
Service d'urologie, hôpital Claude-Huriez, CHRU de Lille, 1, place de Verdun, 59037 Lille cedex, France; Service de génétique clinique, hôpital Jeanne-de-Flandre, avenue Eugène-Avinee, 59037 Lille, France; Faculté de médecine H.-Warembourg, université de Lille II, avenue Eugène-Avinée, 59045 Lille cedex, France; Faculté de médecine H.-Warembourg, université de Lille II, avenue Eugène-Avinée, 59045 Lille cedex, France. ; ; ; ;

Reference: Prog Urol. 2015 Jan 29. pii: S1166-7087(15)00002-0.
doi: 10.1016/j.purol.2015.01.001


PubMed Abstract
PMID: 25640028

Article in French.

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