Fatal neutropenic enterocolitis in a patient with castration-resistant prostate cancer treated with first-line chemotherapy - Abstract

Neutropenic enterocolitis (NE) is a possible life-threatening complication to chemotherapy.

The pathogenesis is multi-factorial with mucosal injury and impaired mucosal defence as contributing factors. Histopathological findings are hetero-geneous. Clinical presentation includes neutropenia, fever and abdominal pain. Treatment is not clearly defined. We present a fatal case of NE in a patient with prostate cancer treated with first-line chemotherapy, docetaxel 75 mg/m2 every three weeks and prednisolone 5 mg × 2 daily. The post-mortem examination confirmed NE with prostate cancer cells in bowel wall.

Written by:
Kongsted P, Sheikh K, Mouritsen LS, Lindberg H, Sengeløv L.   Are you the author?
Vesterbrogade 51, 4. tv., 1620 København V.  

Reference: Ugeskr Laeger. 2015 Jan 26;177(2A). pii: V06130387.

PubMed Abstract
PMID: 25612951

Article in Danish.

UroToday.com Prostate Cancer Section


Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.