Fatal neutropenic enterocolitis in a patient with castration-resistant prostate cancer treated with first-line chemotherapy - Abstract

Neutropenic enterocolitis (NE) is a possible life-threatening complication to chemotherapy.

The pathogenesis is multi-factorial with mucosal injury and impaired mucosal defence as contributing factors. Histopathological findings are hetero-geneous. Clinical presentation includes neutropenia, fever and abdominal pain. Treatment is not clearly defined. We present a fatal case of NE in a patient with prostate cancer treated with first-line chemotherapy, docetaxel 75 mg/m2 every three weeks and prednisolone 5 mg × 2 daily. The post-mortem examination confirmed NE with prostate cancer cells in bowel wall.

Written by:
Kongsted P, Sheikh K, Mouritsen LS, Lindberg H, Sengeløv L.   Are you the author?
Vesterbrogade 51, 4. tv., 1620 København V.  

Reference: Ugeskr Laeger. 2015 Jan 26;177(2A). pii: V06130387.

PubMed Abstract
PMID: 25612951

Article in Danish.

UroToday.com Prostate Cancer Section