Neutropenic enterocolitis (NE) is a possible life-threatening complication to chemotherapy.
The pathogenesis is multi-factorial with mucosal injury and impaired mucosal defence as contributing factors. Histopathological findings are hetero-geneous. Clinical presentation includes neutropenia, fever and abdominal pain. Treatment is not clearly defined. We present a fatal case of NE in a patient with prostate cancer treated with first-line chemotherapy, docetaxel 75 mg/m2 every three weeks and prednisolone 5 mg × 2 daily. The post-mortem examination confirmed NE with prostate cancer cells in bowel wall.
Kongsted P, Sheikh K, Mouritsen LS, Lindberg H, Sengeløv L. Are you the author?
Vesterbrogade 51, 4. tv., 1620 København V.
Reference: Ugeskr Laeger. 2015 Jan 26;177(2A). pii: V06130387.
Article in Danish.