Urethral toxicity after LDR brachytherapy: Experience in Japan - Abstract

Urinary toxicity is common after low-dose-rate (LDR) brachytherapy, and the resolution of urinary toxicity is a concern.

In particular, urinary frequency is the most common adverse event among the urinary toxicities. We have previously reported that approximately 70% of patients experience urinary frequency during the first 6 months after seed implantation. Most urinary adverse events were classified as Grade 1, and Grade 2 or higher adverse events were rare. The incidence of urinary retention was approximately 2-4%. A high International Prostate Symptom Score before seed implantation was an independent predictor of acute urinary toxicity of Grade 2 or higher. Several previous reports from the United States also supported this trend. In Japan, LDR brachytherapy was legally approved in 2003. A nationwide prospective cohort study entitled Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 Seed Implantation was initiated in July 2005. It is an important issue to limit urinary toxicities in patients who undergo LDR brachytherapy.

Written by:
Tanaka N, Asakawa I, Hasegawa M, Fujimoto K.   Are you the author?
Department of Urology, Nara Medical University, Kashihara, Japan; Department of Radiation Oncology, Nara Medical University, Kashihara, Japan.  

Reference: Brachytherapy. 2014 Nov 6. pii: S1538-4721(14)00661-8.
doi: 10.1016/j.brachy.2014.09.009.

PubMed Abstract
PMID: 25455383

UroToday.com Prostate Cancer Section


Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.