11C-choline PET/CT and multiparametric MRI in patients with biochemical relapse of prostate cancer - Abstract

CLINIC PROBLEM AND CASE SERIES: To assess the diagnostic usefulness of 11C-choline PET/CT vs. multi-parametric MRI in the prostate cancer relapse.

A retrospective study of 21 patients with prostate cancer treated initially with surgery (n=12), radiotherapy (n=9). PSA levels were increased (post-surgery: .3-3.6ng/ml; post-radiotherapy: 2.4-8.8ng/ml). In an interval of time of 15 days all patients were underwent to: whole-body-dual-modality PET-CT carried out early after 11C-choline (296±29MBq) injection, and multiparametric prostate MRI with paramagnetic intravenous contrast (using anatomical imaging sequences, diffusion-weighted imaging and dynamic contrast-enhanced imaging). On the basis of our results, all patients were underwent to directed diagnosis and/or clinical, analytic and imaging follow-up. In 15 patients (71.4%) both procedures showed concordant results: 4 negative and 11 positive cases (7 local recurrences, 3 isolated pelvic lymph nodes (2 infracentimetric), 1 local relapse and only one M1 bone metastases). The results were discordant in 6 patients (28.6%): 3 local relapses in MRI with no PET significance, 1 local relapse in PET with no MRI significance. 2 bone metastases were identified with PET (out of the field-of-view of MRI) COMENT: 11C-choline PET/CT and multi-parametric MRI play a complementary role in the detection of local relapse in prostate cancer patients, with similar sensitivity for the detection of lymph involvement. Whole-body 11C-choline PET/CT technique is also useful for bone staging.

Written by:
Garcia JR, Romera N, Cozar M, Soler M, Moragas M, Escobar M.   Are you the author?
Unidad PET/TC, CETIR, España; Servicio de Radiología, Centro Médico Teknon, Barcelona, España.  

Reference: Actas Urol Esp. 2014 Nov 15. pii: S0210-4806(14)00373-8.
doi: 10.1016/j.acuro.2014.10.004


PubMed Abstract
PMID: 25454265

Article in English, Spanish.

UroToday.com Prostate Cancer Section

E-Newsletters

Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.

Subscribe