BACKGROUND: The few previous studies examining the association between asthma or allergy and prostate cancer (PCa) risk were inconclusive.
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This study aimed to evaluate these associations, and to explore in details the possible influence of current versus former allergic condition, age at onset, time since onset, and duration of each allergic condition.
METHODS: Detailed information on self-reported asthma and allergy was collected in the context of a large population-based case-control study conducted in Montreal, Canada. Study subjects included 1936 cases, diagnosed between 2005 and 2009, and 1995 population controls. Unconditional multivariate logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) adjusting for age, ancestry and familial history of prostate cancer.
RESULTS: The ORs were 1.11 (95% CI: 0.89-1.40) and 0.98 (95% CI: 0.84-1.14) for ever reporting of asthma and allergy, respectively. These ORs did not substantially vary according to status (former or current), age at onset, time since onset, and duration of each allergic condition. PCa screening was not associated with allergic diseases reporting.
CONCLUSIONS: Overall, our findings are in line with the absence of an association between a history of asthma or allergy, and PCa risk.
Weiss D, El-Zein M, Rousseau MC, Richard H, Karakiewicz PI, Parent MÉ. Are you the author?
Epidemiology and Biostatistics Unit, INRS-Institut Armand-Frappier, Université du Québec, Laval, Québec, Canada; Department of Social and Preventive Medicine, Université de Montréal, Montréal, Québec, Canada; University of Montreal Hospital Research Centre (CRCHUM), Montréal, Québec, Canada; Epidemiology and Biostatistics Unit, INRS-Institut Armand-Frappier, Université du Québec, Laval, Québec, Canada.
Reference: Cancer Epidemiol. 2014 Dec;38(6):695-9.