Efficacy of high-dose palliative radiotherapy for localised, castration-resistant prostate cancer - Abstract

AIMS: There are limited outcome data after radiotherapy treatment for clinically localised, castration-resistant prostate cancer.

We report our single institution experience on patient outcomes in this group using high-dose palliative radiotherapy (HDPRT).

MATERIALS AND METHODS: A retrospective review of patient hospital records was conducted in prostate cancer patients treated with palliative intent radiotherapy and restricted to those who had castration-resistant disease, no evidence of regional or distant disease and who received a local radiotherapy dose equivalent to 40 Gy or greater.

RESULTS: Fifty-one patients met the study criteria, 88% of these had high-risk disease at initial diagnosis. The median time to delivery of HDPRT was 66 months and the median follow-up from HDPRT was 54 months. Grade 3 or worse toxicity was experienced in 8%. The estimated freedom from local failure, cause-specific survival and overall survival at 5 years were 81, 65 and 35%, respectively. Local procedures were a significant contributor to local morbidity, with the most common procedure a transurethral resection of the prostate (27% patients). Only two patients died from complications of local failure.

CONCLUSION: HDPRT was well tolerated and provided a high rate of local control in a clinically localised castration-resistant prostate cancer population. Although prostate cancer remained the most frequent cause of death, some patients had extended survival without evidence of disease progression.

Written by:
White R, Khor R, Bressel M, Duchesne G, Williams S, Bowden P, Tai K, Foroudi F.   Are you the author?
Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia; Centre for Biostatistics and Clinical Trials, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Department of Biochemistry, Monash University, Melbourne, VIC, Australia; Department of Medical Radiations, Monash Univeristy, Melbourne, VIC, Australia; Radiation Oncology, Epworth Healthcare, Melbourne, VIC, Australia.  

Reference: Clin Oncol (R Coll Radiol). 2015 Jan;27(1):16-21.
doi: 10.1016/j.clon.2014.09.013

PubMed Abstract
PMID: 25445554

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