Preliminary study of combining T2-weighted imaging, diffusion weighted imaging and dynamic contrast enhanced-magnetic resonance imaging for diagnosing prostatic central gland cancer - Abstract

OBJECTIVE: To explore the value of combining T₂-weighted imaging (T₂WI), diffusion weighted imaging (DWI) and dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) for qualitatively diagnosing central gland prostate cancer (CGPCa) as a gold standard with pathologic findings.

METHODS: A total of 42 cases with CGPCa and 42 cases with benign prostate hyperplasia (BPH) proved by pathology were followed up with T₂WI, DWI and DCE-MRI examinations retrospectively. The diagnosis sensitivity and specificity by T2WI, DWI, DCE-MRI alone and combination were calculated respectively. And the consistency of MRI diagnosis and pathological results was judged by Kappa value and the diagnostic value of each method evaluated by Az of receiver operating characteristic curve.

RESULTS: While using T2WI alone, the diagnostic sensitivity, specificity, Az and Kappa value was 66.7%, 76.2%, 0.714 and 0.429; DWI 78.6%, 81.0%, 0.798 and 0.595; DCE-MRI 83.3%, 61.9%, 0.726 and 0.452, Az between DWI and T₂WI was statistically significant (P < 0.05) while DCE-MRI insignificant (P > 0.05). When combining T₂WI+DWI+DCE-MRI, the diagnostic sensitivity, specificity, Az and Kappa value was 90.5%, 88.1%, 0.893 and 0.786, Az between T₂WI+DWI+DCE-MRI and T₂WI, DWI and DCE-MRI was statistically significant respectively (all P < 0.05).

CONCLUSION: DWI is better than T₂WI for diagnosing CGPCa. Combining T₂WI+DWI+DCE-MRI can obviously improve the diagnostic accuracy of CGPCa. And it has excellent consistency with pathological analysis.

Written by:
Li P, Yang W, Chen Z, Guo Y, Cai L, Du Y, Li Y.   Are you the author?
Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan 750004, China.  

Reference: Zhonghua Yi Xue Za Zhi. 2014 Aug 19;94(31):2448-51.


PubMed Abstract
PMID: 25400054

Article in Chinese.

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