Focal cryotherapy of localized prostate cancer: A systematic review of the literature - Abstract

Radical/whole gland treatment for prostate cancer has significant side-effects.

Therefore focal treatments such as cryotherapy have been used to treat localized lesions whilst aiming to provide adequate cancer control with minimal side-effects. We performed a systematic review of Pubmed/Medline and Cochrane databases' to yield 9 papers for primary focal prostate cryotherapy and 2 papers for focal salvage treatment (radio-recurrent). The results of 1582 primary patients showed biochemical disease-free survival between 71-93% at 9-70 months follow-up. Incontinence rates were 0-3.6% and ED 0-42%. Recto-urethral fistula occurred in only 2 patients. Salvage focal cryotherapy had biochemical disease-free survival of 50-68% at 3 years. ED occurred in 60-71%. Focal cryotherapy appears to be an effective treatment for primary localized prostate cancer and compares favorably to radical/whole gland treatments in medium-term oncological outcomes and side-effects. Although more studies are needed it is also effective for radio-recurrent cancer with a low complications rates.

Written by:
Shah TT, Ahmed H, Kanthabalan A, Lau B, Ghei M, Maraj B, Arya M.   Are you the author?
Division of Surgery and Interventional Science, University College London, London, UK.

Reference: Expert Rev Anticancer Ther. 2014 Nov;14(11):1337-47.
doi: 10.1586/14737140.2014.965687

PubMed Abstract
PMID: 25367324 Prostate Cancer Section