Positive surgical margin trends in patients with pathologic T3 prostate cancer treated with robot assisted radical prostatectomy - Abstract

INTRODUCTION: We analyzed the trends of positive surgical margin (PSM) location in patients that had pT3 disease at robotic assisted radical prostatectomy (RARP).

We aimed to describe our changing incidence of positive surgical margins in the largest series to date of patients with pT3 disease treated by RARP.

METHODS: A single-institution, single-surgeon review was done of all patients who underwent RARP from 2005 to 2011. Perioperative data was collected for all patients with pT3 prostate cancer from a prospectively maintained RARP database. The PSM incidence and rates were stratified by location. The PSM rates per location were trended over time.

RESULTS: In total, 2,478 consecutive patients underwent RARP between July 2005 and December 2011. Of these patients, 555 were found to have pT3 disease. The PSM rate for patients with pT3 disease was 47%. The PSM rate for patients with pT3A and pT3B disease was 42.8% and 60.6%, respectively. Over the duration of this study the PSM rate in patients with pT3 disease decreased significantly from 70.6% in 2005 to 32.3% in 2011 (p=0.002). The apical PSM rate showed the greatest decrease during this time period going from 52.9% in 2005 to 5.2% in 2011 (p=0.018).

CONCLUSION: We present the largest series to date involving the treatment of locally advanced prostate cancer initially treated with RARP. Our findings suggest that locally advanced prostate cancer can be treated with RARP with acceptable positive margin rates. Overall PSM rates improved nearly 40% over the 6.5 year period of this study.

Written by:
Lightfoot AJ, Su YK, Sehgal SS, Lee Z, Greaves GH, Yu SJ, Llukani E, Su YC, Lee D.   Are you the author?
University of Pennsylvania, Urology, Philadelphia, Pennsylvania, United States.  

Reference: J Endourol. 2014 Oct 30. Epub ahead of print.
doi: 10.1089/end.2014.0242.ECC

PubMed Abstract
PMID: 25356630

UroToday.com Prostate Cancer Section


Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.