The association between prostate cancer and mood disorders: A nationwide population-based study in Taiwan - Abstract

Background: This study identified possible risk factors for newly diagnosed mood disorders, including depressive and bipolar disorders, in prostate cancer patients.

Methods: From 2000 to 2006, two cohorts were evaluated on the occurrence of mood disorder diagnosis and treatment. For the first cohort, data of patients diagnosed with prostate cancer was obtained from the Taiwan National Health Insurance (NHI) Research Database. As the second cohort, a cancer-free comparison group was matched for age, comorbidities, geographic region, and socioeconomic status.

Results: Final analyses involved 12,872 men with prostate cancer and 12,872 matched patients. Increased incidence of both depressive (IRR 1.52, 95% CI 1.30-1.79, P < 0.001) and bipolar disorder (IRR 1.84, 95% CI 1.25-2.74, P = 0.001) was observed among patients diagnosed with prostate cancer. Multivariate matched regression models show that cerebrovascular disease (CVD) and radiotherapy treatment could be independent risk factors for developing subsequent depressive and bipolar disorders.

Conclusion: We observed that the risk of developing newly diagnosed depressive and bipolar disorders is higher among Taiwanese prostate cancer patients. Clinicians should be aware of the possibility of increased depressive and bipolar disorders among prostate cancer patients in Taiwan. A prospective study is necessary to confirm these findings.

Written by:
Chen PM, Chen SC, Liu CJ, Hung MH, Tsai CF, Hu YW, Chen MH, Shen CC, Su TP, Yeh CM, Lu T, Chen TJ, Hu LY.   Are you the author?
Department of Psychiatry, Yuanshan Branch, Taipei Veterans General Hospital, Yilan, Taiwan; Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Psychiatry, Taipei Veterans General Hospital,Taipei, Taiwan; Cancer Center, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Psychiatry, Chiayi Branch, Taichung Veterans General Hospital, Chiayi, Taiwan; Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Psychiatry, Kaohsiung Veterans General Veterans Hospital, Kaohsiung City, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Reference: Int Psychogeriatr. 2014 Oct 22:1-10.
doi: 10.1017/S104161021400218X


PubMed Abstract
PMID: 25335499

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