Permanent prostate brachytherapy and short-term androgen deprivation for intermediate-risk prostate cancer in Japanese men: Outcome and toxicit - Abstract

OBJECTIVES: To evaluate the interim outcomes of low-dose-rate permanent brachytherapy (PB) combined with short-term androgen deprivation therapy (ADT) in Japanese men with intermediate-risk prostate cancer excluding those with a Gleason score of 4+3.

METHODS: The Protocol-intermediate-risk group (Protocol-IRG) was defined as clinical stage T1c-T2c, Gleason score of 3+4, or lower and prostatic-specific antigen (PSA) level lower than 20ng/mL. A total of 308 patients underwent brachytherapy in the protocol-IRG group (n=152) or in the low-risk group (n=156). Patients in Protocol-IRG had received at least 6 months of ADT before and after PB. Supplemental external beam radiotherapy was not used. Planned followup by PSA was carried out every 3 months for the first 2 years and every 6 months thereafter. The PSA failure was defined as nadir+2ng/mL. Patients' Expanded Prostate Cancer Index Composite was recorded before and 3 years after treatment.

RESULTS: The median followup was 68 and 68 months for the protocol-IRG and the low-risk groups, respectively. The 5-year biological disease-free survival rates in the low-risk and protocol-IRG groups were 94.8 and 94.6%, respectively. As far as survival rates were concerned, there were no significant differences between the two groups. Overall satisfaction and sexual function at 3 years after PB had significantly improved compared with pretreatment (p=0.01 and p=0.01, respectively).

CONCLUSIONS: In intermediate-risk prostate patients, excluding those with a biopsy Gleason score of 4+3, brachytherapy with short-term ADT can be an effective treatment option for Japanese men.

Written by:
Yamada Y, Masui K, Iwata T, Naitoh Y, Yamada K, Miki T, Okihara K.   Are you the author?
Department of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan.  

Reference: Brachytherapy. 2014 Oct 8. pii: S1538-4721(14)00643-6.
doi: 10.1016/j.brachy.2014.09.001

PubMed Abstract
PMID: 25304650 Prostate Cancer Section