Giant subcutaneous hematoma with hemorrhagic shock induced by goserelin acetate injection for prostate cancer: Report of a case - Abstract

A 87-year-old man was diagnosed with prostate cancer (cT2aN0M0 Gleason score 4+4 with initial prostate specific antigen of 23.4 ng/ml).

Prostate cancer was treated with combined androgen blockade (goserelin acetate plus flutamide). He was administered goserelin acetate depot injection without any complications as an outpatient. However, 5 hours after he left the hospital, he came back to the hospital, complaining of lower abdominal pain. Abdominal computed tomography revealed a giant subcutaneous hematoma in the lower abdomen. Hemoglobin was 6.9 g/dl and blood pressure was lower than 80 mmHg. He was admitted and given a blood transfusion. Because of pre-disseminated intravascular coagulation score 6, it was hard to antagonize warfarin by Vitamin K (he had taken warfarin because of atrial fibrillation). Arteriography was performed and injury to a branch of the lower epigastric artery was found. Transcatheter arterial embolization was performed at the same time. Injecting goserelin acetate may cause severe arterial injury.

Written by:
Tashiro K, Kimura S, Naruoka T, Furuta N, Egawa S.   Are you the author?
The Department of Urology, (the) Third Hospital of Jikei University School of Medicine; The Department of Urology, Jikei University School of Medicine.

Reference: Hinyokika Kiyo. 2014 Sep;60(9):455-8.

PubMed Abstract
PMID: 25293802

Article in Japanese. Prostate Cancer Section