Salvage HIFU after radiotherapy and salvage radiotherapy after HIFU in locally recurrent prostate cancer: Retrospective analysis of morbidity - Abstract

OBJECTIVES: To evaluate the toxicity of therapeutic sequences High Intensity Focused Ultrasound (HIFU)-salvage radiotherapy (HIFU-RT) or radiotherapy-salvage HIFU (RT-HIFU) in case of locally recurrent prostate cancer.

MATERIALS AND METHODS: Nineteen patients had a local recurrence of prostate cancer. Among them, 10 patients were treated by HIFU-RT and 9 patients by RT- HIFU (4 by external beam radiotherapy [EBR] and 5 by brachytherapy [BRACHY]). Urinary side effects were assessed using CTCAE v4.

RESULTS: At the time of the initial management, the median age was 66.5 years (53-72), the median PSA was 10.8ng/mL (3.4-50) and the median initial Gleason score was 6.3 (5-8). Median follow-up after salvage treatment was 46.3 months (2-108). Thirty percent of the patients in the HIFU-RT group and 33.3 % of the patients in the RT-HIFU group, all belonging to the sub-group BRACHY-HIFU, had urinary complication greater than or equal to grade 2. Among all the patients, only 1 had grade 1 gastrointestinal toxicity.

CONCLUSION: BRACHY-HIFU sequence seems to be purveyor of many significant urinary side effects. A larger database is needed to confirm this conclusion.

Written by:
Lee JW, Chevallier D, Gal J, Rouscoff Y, Natale R, Chand ME, Raffaelli C, Ambrosetti D, Durand M, Amiel J, Hannoun-Levi JM.   Are you the author?
Département de radiothérapie oncologique, centre Antoine-Lacassagne, université de Nice Sophia Antipolis, 33, avenue de Valombrose, 06189 Nice cedex 2, France; Service d'urologie et de transplantation, hôpital Archet 2, centre hospitalier universitaire de Nice, université de Nice Sophia Antipolis, 151, route de Saint-Antoine, 06202 Nice cedex 3, France; Unité de biostatistiques, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice cedex 2, France; Département de radiologie, hôpital Pasteur, centre hospitalier universitaire de Nice, 30, voie Romaine, 06001 Nice cedex 1, France; Laboratoire central d'anatomie pathologique, hôpital Pasteur, centre hospitalier universitaire de Nice, 30, voie Romaine, 06001 Nice cedex 1, France.  

Reference: Prog Urol. 2014 Sep 17. pii: S1166-7087(14)00445-X.
doi: 10.1016/j.purol.2014.08.235


PubMed Abstract
PMID: 25241245

Article in French.

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