Tissue composition and density impact on the clinical parameters for 125I prostate implants dosimetry - Abstract

The MCNPX code was used to calculate the TG-43U1 recommended parameters in water and prostate tissue in order to quantify the dosimetric impact in 30 patients treated with 125I prostate implants when replacing the TG-43U1 formalism parameters calculated in water by a prostate-like medium in the planning system (PS) and to evaluate the uncertainties associated with Monte Carlo (MC) calculations.

The prostate density was obtained from the CT of 100 patients with prostate cancer. The deviations between our results for water and the TG-43U1 consensus dataset values were -2.6% for prostate V100, -13.0% for V150, and -5.8% for D90; -2.0% for rectum V100, and -5.1% for D0.1; -5.0% for urethra D10, and -5.1% for D30. The same differences between our water and prostate results were all under 0.3%. Uncertainties estimations were up to 2.9% for the gL(r) function, 13.4% for the F(r,θ) function and 7.0% for Λ, mainly due to seed geometry uncertainties. Uncertainties in extracting the TG-43U1 parameters in the MC simulations as well as in the literature comparison are of the same order of magnitude as the differences between dose distributions computed for water and prostate-like medium. The selection of the parameters for the PS should be done carefully, as it may considerably affect the dose distributions. The seeds internal geometry uncertainties are a major limiting factor in the MC parameters deduction.

Written by:
Oliveira SM, Teixeira NJ, Fernandes L, Teles P, Vieira G, Vaz P.   Are you the author?
Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Campo Mártires da Pátria, 130, 1169-056 Lisbon, Portugal; Quadrantes Faro - Unidade de Radioterapia do Algarve, Rua da Associação Oncológica do Algarve, 8000-316 Faro, Portugal; MedicalConsult, SA, Campo Grande, 56-8°A, 1700-093 Lisbon, Portugal; Escola Superior de Tecnologia da Saúde de Lisboa, Instituto Politécnico de Lisboa, Av. D. João II, lote 4.69.01, 1900-096 Lisbon, Portugal; Instituto Gulbenkian de Ciência, Rua da Quinta Grande, 6, 2780-156 Oeiras, Portugal; Centro de Biodiversidade, Genómica Integrativa e Funcional, Faculdade de Ciências, Universidade de Lisboa, Edifício ICAT, Campus FCUL, Campo Grande, 1740-016 Lisbon, Portugal; IST/ITN, Instituto Superior Técnico, Universidade Técnica de Lisboa, Estrada Nacional 10, 2695-006 Bobadela LRS, Portugal; Quadrantes Faro - Unidade de Radioterapia do Algarve, Rua da Associação Oncológica do Algarve, 8000-316 Faro, Portugal.  

Reference: Phys Med. 2014 Sep 16. pii: S1120-1797(14)00146-X.
doi: 10.1016/j.ejmp.2014.06.042

PubMed Abstract
PMID: 25239870

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