Salvage treatments following prostate radiation therapy: Role of the urologist - Abstract

The management of recurrent prostate cancer after radiotherapy or brachytherapy is non-standardized and rapidly evolving.

Local recurrence is observed on average in 30% of cases several years following irradiation. A key challenge is to determine the site of recurrence and imaging (MRI and PET choline) coupled to prostate biopsies are important to confirm the local character. Salvage therapy performed by the urologist can then control the situation. Radical prostatectomy subject to strict technical conditions is one of the most efficient local treatments, however it comes at the cost of significant urinary morbidity; minimally invasive therapies (focused ultrasound and cryotherapy) have also their place in specific indications. Each clinical situation should be discussed in pluridisciplinary meetings integrating the oncologic and functional status at recurrence, the risk/benefit ratio of each treatment, the patient's wishes and probability of survival.

Written by:
Soulié M, Salomon L.   Are you the author?
Département d'urologie, d'andrologie et de transplantation rénale, université Paul-Sabatier, CHU Rangueil, 1, avenue Jean-Poulhès, 31403 Toulouse cedex 4, France; Service d'urologie, université de Créteil, CHU Henri-Mondor, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil cedex, France.  

Reference: Cancer Radiother. 2014 Oct;18(5-6):535-9.
doi: 10.1016/j.canrad.2014.06.002

PubMed Abstract
PMID: 25175343

Article in French. Prostate Cancer Section