Integrated CT-perfusion shows no meaningful correlation with PSA and presurgical Gleason score in patients with early prostate cance - Abstract

OBJECTIVES: To analyze the correlation of computed tomography (CT) perfusion parameters blood flow (BF), blood volume (BV), and mean transit time (MTT) with presurgical prostate cancer data.

METHODS: Ninety-eight patients with biopsy-proven prostate cancer underwent a CT-perfusion scan of the prostate. MTT, BF, and BV were determined and correlated with prostate-specific antigen (PSA) level, tumor load and Gleason score of transrectal ultrasonography-guided biopsy specimens.

RESULTS: Mean BF was 41.3 ml/100 ml*min-1, BV 5.2 ml/100 ml, MTT 8.7 s. Moderate correlations were observed between Gleason score and BF (0.35) and between PSA and BF (0.33) and BV (0.30).

CONCLUSIONS: CT-perfusion shows no valuable correlation with presurgical prostate cancer data.

Written by:
Huellner MW, Mattei A, Ross S, Butea-Bocu M, Vosbeck J, Pauli C, Diebold J, Seifert B, Strobel K, Veit-Haibach P.   Are you the author?
Department of Radiology and Nuclear Medicine, Lucerne Cantonal Hospital, Spitalstrasse 1, 6004 Lucerne, Switzerland; Department of Urology, Lucerne Cantonal Hospital, Spitalstrasse 1, 6004 Lucerne, Switzerland; Institute of Pathology, Lucerne Cantonal Hospital, Spitalstrasse 1, 6004 Lucerne, Switzerland; Division of Biostatistics, Institute for Social and Preventive Medicine, University of Zurich, Hirschengraben 84, 8001 Zurich, Switzerland.  ; ; ; ; ; ; ; ; ;

Reference: Clin Imaging. 2014 Aug 2. pii: S0899-7071(14)00179-X.
doi: 10.1016/j.clinimag.2014.07.011


PubMed Abstract
PMID: 25168905

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