A 59-year-old man had an elevated prostate-specific antigen (PSA) concentration (439 ng/mL) in December 2008.
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We diagnosed prostatic adenocarcinoma by prostate needle biopsy. CT and MRI showed a prostatic tumour with bone and lymph node metastases. Combined androgen blockade therapy reduced the PSA level temporarily. After the PSA level gradually started to increase again and reached 27.27 ng/mL in October 2010, the patient was diagnosed with castration-resistant prostate cancer and treated with docetaxel chemotherapy. Radiological examination detected left hydronephrosis and a tumour in the left lower ureter in March 2011. Retrograde pyelography and urine cytology of class 3 from the left ureter indicated that the ureteral mass was a urothelial carcinoma. A left nephroureterectomy was performed. After the operation, the pathological examination showed a metastatic prostate carcinoma, accompanied by a decrease in the serum PSA level from 59.56 to 45.33 ng/mL.
Hongo H, Kosaka T, Yoshimine S, Oya M. Are you the author?
Department of Urology, Kieo University, Tokyo, Japan; Department of Urology, Fussa Hospital, Tokyo, Japan.
Reference: BMJ Case Rep. 2014 Aug 28;2014. pii: bcr2014206736.