Total submission of lymphadenectomy tissues removed during radical prostatectomy for prostate cancer: Possible clinical significance of large-format histology - Abstract

Complete submission of lymphadenectomy specimens increases the number of recovered lymph nodes and the detection of metastatic disease.

There are advantages with the whole-mount technique over complete sampling with standard cassettes in terms of time needed to sample the tissue, number of blocks to be cut, and slides to be examined. The clinical significance of the approach is that all lymph nodes are identified, including those that are not palpable. In particular, this approach avoids the fact that an individual lymph node is oversampled and counted according to number of pieces obtained by the pathologist, mainly in nodes with considerable size.

Written by:
Montironi R, Scarpelli M, Galosi AB, Lopez-Beltran A, Mazzucchelli R, Montorsi F, Cheng L.   Are you the author?
Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, 60126 Ancona, Italy; Urology Division, Murri Hospital, 63900 Fermo, Italy; Unit of Anatomic Pathology, Department of Surgery, Faculty of Medicine, E14004 Cordoba, Spain; Fundação Champalimaud, 1400-038 Lisbon, Portugal; Department of Urology, University Vita-Salute, Scientific Institute H San Raffaele, 20132 Milan, Italy; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.  

Reference: Hum Pathol. 2014 Jul 17. pii: S0046-8177(14)00279-2.
doi: 10.1016/j.humpath.2014.06.023

PubMed Abstract
PMID: 25149553 Prostate Cancer Section