OBJECTIVE: To evaluate the clinical significance of transrectal real-time elastography (TRTE) in diagnosis of prostate cancer (PCA).
METHODS: 195 patients with an elevated PSA level were enrolled in the study. A novel 5-grading score of prostate outer gland was applied by TRTE imaging. Receiver-operating characteristic curve (ROC) analyses were performed to assess the diagnostic performance of TRTE score.
RESULTS: TRTE scores in patients with PCA and benign condition were 3.20 ± 1.11 (range: 1-5) and 2.24 ± 1.01 (range: 1-4), respectively (P < 0.001). The best cutoff value of TRTE score was 3, and the sensitivity, specificity, accuracy in the diagnosis were 68.6% (35/51), 69.4% (100/144) and 69.2% (135/195), respectively. The accuracy of TRTE in volume ≤ 30 ml group was significantly higher than that in the volume ≥ 50 ml group and the 30-50 ml group (76.9% vs. 65.0% and 76.9% vs. 71.4%, both P < 0.001). Accuracy of TRTE score was higher for those with PSA ranged 4-10 ng/ml than those with PSA > 10 ng/ml (85.3% vs. 66.7%, P = 0.002).
CONCLUSION: TRTE score, a novel semi-quantitative assessment of patients' prostate stiffness, can be served as a useful screening method for patients suspicious of PCA, especially those only having an elevated PSA level.
Written by:
Xu G, Feng L, Yao M, Wu J, Guo L, Yao X, Zhao L, Xu H, Wu R. Are you the author?
Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University Shanghai 200072, China; Department of Pathology, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University Shanghai 200072, China; Department of Urology, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University Shanghai 200072, China.
Reference: Int J Clin Exp Pathol. 2014 Jun 15;7(7):4128-35.
PubMed Abstract
PMID: 25120792