Organ and function preservation in prostate cancer - Abstract

BACKGROUND: Curative treatment for prostate cancer is associated with risks which may adversely influence quality of life.

Furthermore, there is a considerable rate of overdiagnosis of tumors which would be non-life-threatening if left untreated. Efforts have been made to reduce overtreatment.

DISCUSSION: Beside the traditional conservative symptomatic management especially in elderly patients with meaningful comorbidity, several prostate-sparing or deferred treatment options are currently discussed. For all of them, insufficient data on efficacy and safety are available.

RESULTS: Because of the required long-term follow-up of large sample sizes, conclusive data will not become available in the near future. Therefore, these treatment options have to be considered experimental to a large degree. This applies both to focally ablative techniques and to active surveillance of prostate cancer in patients with a long further life expectancy. Only in carefully selected patients with favorable tumor-associated risk profiles and high risk of medium-term competing mortality may active surveillance be considered a valid and relatively safe treatment option.

Written by:
Fröhner M, Wirth M.   Are you the author?
Klinik und Poliklinik für Urologie, Universitätsklinikum "Carl Gustav Carus" der Technischen Universität Dresden, Fetscherstraße 74, 01307, Dresden, Deutschland.  

Reference: Urologe A. 2014 Sep;53(9):1295-301.
doi: 10.1007/s00120-014-3526-0

PubMed Abstract
PMID: 25104234

Article in German. Prostate Cancer Section