The clinical value of dynamic contrast-enhanced magnetic resonance imaging at 3.0T to detect prostate cancer - Abstract

OBJECTIVE: To compare dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and T2-weighted imaging (T2WI) at 3.0T for detection of prostate cancer.

METHODS: Patients with elevated prostate-specific antigen underwent T2WI and DCE-MRI prior to prostate needle biopsy. The sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of T2WI and DCE-MRI to diagnose prostate cancer were evaluated. The relationship between Gleason score and prostate cancer detection by DCE-MRI was evaluated.

RESULTS: Prostate adenocarcinoma was histopathologically confirmed in 44/75 patients. DCE-MRI had significantly higher sensitivity, accuracy and NPV than T2WI. The detection rate of prostate cancer by DCE-MRI was significantly better for tumours with Gleason score 7-9 than for those Gleason score 4-6.

CONCLUSION: DCE-MRI at 3.0T can significantly improve prostate cancer detection using simple visual diagnostic criteria, compared with T2WI.

Written by:
Zhang X, Quan X, Lu S, Huang F, Yang J, Chan Q, Lin T.   Are you the author?
Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China; Philips Healthcare, Hong Kong, China.  

Reference: J Int Med Res. 2014 Aug 4. pii: 0300060514541827.
doi: 10.1177/0300060514541827

PubMed Abstract
PMID: 25091389 Prostate Cancer Section