Toxicity outcome in patients treated with modulated arc radiotherapy for localized prostate cancer - Abstract

AIM: This study evaluates the acute toxicity outcome in patients treated with RapidArc for localized prostate cancer.

BACKGROUND: Modern technologies allow the delivery of high doses to the prostate while lowering the dose to the neighbouring organs at risk. Whether this dosimetric advantage translates into clinical benefit is not well known.

MATERIALS AND METHODS: Between December 2009 and May 2012, 45 patients with primary prostate adenocarcinoma were treated using RapidArc. All patients received 1.8 Gy per fraction, the median dose to the prostate gland, seminal vesicles, pelvic lymph nodes and surgical bed was 80 Gy (range, 77.4-81 Gy), 50.4 Gy, 50.4 Gy and 77.4 Gy (range, 75.6-79.2 Gy), respectively.

RESULTS: The time between the last session and the last treatment follow up was a median of 10 months (range, 3-24 months). The incidence of grade 3 acute gastrointestinal (GI) and genitourinary (GU) toxicity was 2.2% and 15.5%, respectively. Grade 2 acute GI and GU toxicity occurred in 30% and 27% of patients, respectively. No grade 4 acute GI and GU toxicity were observed. Older patients (>median) or patients with V60 higher than 35% had significantly higher rates of grade ≥2 acute GI toxicity compared with the younger ones.

CONCLUSIONS: RapidArc in the treatment of localized prostate cancer is tolerated well with no Grade >3 GI and GU toxicities. Older patients or patients with higher V60 had significantly higher rates of grade ≥2 acute GI toxicity. Further research is necessary to assess definitive late toxicity and tumour control outcome.

Written by:
Lengua RE, Gonzalez MF, Barahona K, Ixquiac ME, Lucero JF, Montenegro E, Lopez Guerra JL, Jaén J, Linares LA.   Are you the author?
Department of Radiation Oncology, Hope International Radiotherapy Center, Guatemala City, Guatemala; Department of Radiation Oncology, Virgen del Rocío University Hospital, Seville, Spain; Department of Radiation Oncology, Instituto Oncológico Cartuja-Grupo IMO, Seville, Spain.

Reference: Rep Pract Oncol Radiother. 2013 Oct 24;19(4):234-8.
doi: 10.1016/j.rpor.2013.09.007

PubMed Abstract
PMID: 25061516 Prostate Cancer Section








Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.