Carboplatin plus etoposide in heavily pretreated castration-resistant prostate cancer patients - Abstract

Aims: Carboplatin plus etoposide has modest efficacy in docetaxel-pretreated castration-resistant prostate cancer patients.

We hypothesized that carboplatin-etoposide could still exert some therapeutic activity after docetaxel, cabazitaxel and either abiraterone or enzalutamide.

Patients & Methods: We enrolled 15 patients in the first step of a Phase II trial. The target sample size is 46 patients. The primary end point of the study was progression-free survival after 12 weeks.

Results: The median progression-free survival was 11 weeks (range: 8-18), while median overall survival was 18 weeks (range: 12-26). Of seven patients with measurable disease, two had a partial response, two showed stable disease and the remaining three had progressive disease as the best radiological response. Five patients were considered progression-free after 12 weeks, prompting continuation of the trial.

Conclusion: Our preliminary findings support the hypothesis that carboplatin plus etoposide may yield some clinical benefit in a population of patients who failed all currently approved therapeutic options for prostate cancer.

Written by:
Buonerba C, Federico P, Bosso D, Puglia L, Policastro T, Izzo M, Perri F, Vittoria Scarpati GD, Ferro M, Cobelli OD, De Placido S, Aieta M, Imbimbo C, Longo N, Di Lorenzo G.   Are you the author?
Genitourinary Cancer Section, Medical Oncology Division, Department of Clinical Medicine, University Federico II, Napoli, Italy.

Reference: Future Oncol. 2014 Jun;10(8):1353-60.
doi: 10.2217/fon.14.71

PubMed Abstract
PMID: 25052746 Prostate Cancer Section