OBJECTIVE: To perform a head to head comparison of these two nomograms by an external validation combined with an identification of probability cut-offs when to indicate NS.
METHODS: The full models of the nomograms of Ohori et al. and Steuber et al. were used to calculate the risk of ECE based on PSA and side specific information on clinical stage, biopsy Gleason score, % positive cores, and % cancer in cores. A dataset of 968 prostate half lobes was used retrospectively for analysis. All patients underwent laparoscopic robot-assisted or open radical prostatectomy for localized prostate cancer.
RESULTS: The predictive accuracy of the Ohori nomogram was at 0.80 and for the Steuber Nomogram at 0.78 (comparison P>0.05). In the calibration plot, the Ohori nomogram showed less departures from ideal predictions than the Steuber nomogram. The best probability cut-off to allow NS for the Ohori nomogram seemed to be ≤ 10%, permitting NS in 59.7% of all cases and being associated with a false negative rate of 10%. The best cut-off for the Steuber nomogram seemed to be ≤ 8%, permitting NS in 44% and associated with a false negative rate 12.5%.
CONCLUSIONS: The Ohori et al. and the Steuber et al. nomograms allow highly accurate and comparable predictions of the risk of side specific ECE.
Written by:
Clement C, Maurin C, Villeret J, Marcy M, Salem N, Brunelle S, Gravis G, Garcia S, Giusiano S, Bastide C, Rossi D, Bladou F, Walz J. Are you the author?
Service d'urologie, hôpital Nord, chemin des Bourrelys, 13015 Marseille, France; Aix-Marseille université, 13284 Marseille, France; Service d'urologie et transplantation rénale, hôpital La Conception, AP-HM, 13385 Marseille, France; Service d'anatomo-pathologie, hôpital Nord, 13015 Marseille, France; Service d'anatomo-pathologie, institut Paoli-Calmettes, 13009 Marseille, France; Service de radiothérapie, institut Paoli-Calmettes, 13009 Marseille, France; Service de radiologie, institut Paoli-Calmettes, 13009 Marseille, France; Service d'oncologie, institut Paoli-Calmettes, 13009 Marseille, France; Service d'urologie, Jewish hospital, QC H3TIE2 Montreal, Canada; Service d'urologie, institut Paoli-Calmettes, 13009 Marseille, France.
Reference: Prog Urol. 2014 Jul;24(9):581-7.
doi: 10.1016/j.purol.2014.03.003
PubMed Abstract
PMID: 24975793
Article in French.
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