A randomized trial of diet in men with early stage prostate cancer on active surveillance: Rationale and design of the Men's Eating and Living (MEAL) Study (CALGB 70807 [Alliance]) - Abstract

BACKGROUND: Diet may substantially alter prostate cancer initiation and progression.

However, large-scale clinical trials of diet modification have yet to be performed for prostate cancer. The Men's Eating and Living (MEAL) Study (CALGB 70807 [Alliance]) is investigating the effect of increased vegetable consumption on clinical progression in men with localized prostate cancer.

STUDY DESIGN: MEAL is a randomized, phase III clinical trial designed to test whether an intervention that increases vegetable intake will decrease the incidence of clinical progression in men with clinically localized prostate cancer on active surveillance. We are randomizing 464 patients to either a validated telephone-based diet counseling intervention or a control condition in which patients receive a published diet guideline. The intervention will continue for two years. The primary outcome variable is clinical progression defined by serum prostate-specific antigen (PSA) and pathological findings on follow-up prostate biopsy. Secondary outcome variables include incidence of surgical and non-surgical treatments for prostate cancer, prostate-cancer related patient anxiety and health-related quality of life.

CONCLUSION: The MEAL Study is assessing the effectiveness of a high-vegetable diet intervention for preventing clinical progression in men with localized prostate cancer on active surveillance.

Written by:
Parsons JK, Pierce JP, Mohler J, Paskett E, Jung SH, Humphrey P, Taylor JR, Newman VA, Barbier L, Rock CL, Marshall J.   Are you the author?
Division of Urologic Oncology, UC San Diego Moores Cancer Center, La Jolla, CA, United States; Department of Urology, UC San Diego Health System, La Jolla, CA, United States; VA San Diego Healthcare System, La Jolla, CA, United States; 2Department of Family and Preventive Medicine, University of California, San Diego School of Medicine, La Jolla, CA, United States; Department of Urology, Roswell Park Cancer Institute, Buffalo, NY, United States; Department of Medicine, College of Medicine, Comprehensive Cancer Center, Ohio State University, Columbus, OH, United States; Alliance Statistics and Data Center, Duke University Medical Center, Durham, NC, United States; Department of Pathology, Washington University Medical School, St. Louis, MO, United States; 7Alliance Central Protocol Operations, University of Chicago, Chicago, IL, United States; Department of Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, NY, United States.  

Reference: Contemp Clin Trials. 2014 May 13;38(2):198-203.
doi: 10.1016/j.cct.2014.05.002

PubMed Abstract
PMID: 24837543

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Read J. Kellogg Parsons 2018 AUA Presentation: The Men’s Eating and Living (MEAL) Study: A Randomized Clinical Trial of a Diet Intervention in Men on Active Surveillance for Prostate Cancer