OBJECTIVE: To evaluate the impact of obesity on prostate cancer detection, as measured by the body mass index (BMI) in a Korean biopsy population.
PATIENTS AND METHODS: We retrospectively reviewed the records of 1,213 men who underwent transrectal ultrasound guided prostate biopsy at our institution. Biopsy outcomes were analyzed with respect to various variables, including patient age, prostate-specific antigen (PSA), prostate volume, digital rectal exam (DRE) finding, and obesity defined as BMI ≥ 25 kg/m2 as an Asian BMI category.
RESULTS: Among 1213 men, 408 (33.6%) were obese, and 344 (28.4%) had a positive biopsy. Obese men were younger (65.5 vs 67.1 years, p = 0.003), had a larger prostate (49.2 vs 42.9 cc, p < 0.001), were less likely to have any abnormality on DRE (8.1% vs 15.9% p < 0.001). In the multivariate analysis, obesity was significantly associated with a higher risk of detection on prostate cancer in biopsy subjects (OR = 1.446, P = 0.024). Also, obesity was significantly associated with a higher rate of high-grade (Gleason score ≥4 + 3) diseases detected from the biopsy, and this association remained after multivariate adjustment (OR = 1.498, P = 0.039).
CONCLUSION: Obese men were younger, had a larger prostate, and had less tendency to have an abnormality on DRE. Obesity was associated with a higher risk of prostate cancer detection as an independent factor, including high-grade prostate cancer in a Korean biopsy population.
Written by:
Park J, Cho SY, Lee SB, Son H, Jeong H. Are you the author?
Department of Urology, Aerospace Medical Center, Cheongwon-Gun, Choongchungbuk-Do, Republic of Korea.
Reference: BJU Int. 2013 Dec 9. Epub ahead of print.
doi: 10.1111/bju.12600
PubMed Abstract
PMID: 24314095
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