The authors describe a male patient who developed a large intracranial meningioma during the hormone therapy for pre-existing prostate cancer.
A 70-year-old man received a brain check-up, and no intracranial abnormality was detected. Five months later, prostate cancer was diagnosed, and he underwent prostatectomy. Leuprorelin acetate, a luteinizing hormone-releasing hormone (LH-RH) agonist, was subsequently administered to the patient once a month for 3 years. After that he presented with a large parasagittal mass, which was excised. The tumor was histologically diagnosed as meningothelial meningioma, and LH-RH receptors were verified immunohistochemically in the cytoplasm of the tumor cells. Leuprorelin acetate may accelerate the rapid growth of meningioma in this patient.
Written by:
Anda T, Honda M, Ishihara T, Kamei T. Are you the author?
Department of Neurosurgery, Shunan Memorial Hospital.
Reference: Neurol Med Chir (Tokyo). 2013 Nov 8. Epub ahead of print.
doi: 10.2176/nmc.cr2012-0417
PubMed Abstract
PMID: 24201100
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