The surgical approach can be determined from the pathological specimen obtained after open or robot-assisted laparoscopic radical prostatectomy - Abstract

PURPOSE: To assess the surgical approach using the pathological specimen obtained after open radical prostatectomy (ORP) or robot-assisted radical prostatectomy (RALRP).

METHODS: A prospective study has been performed in patients who underwent either ORP or RALRP for localized prostate cancer. Two dedicated uro-pathologists, blinded to the surgeons and the operating rooms' schedules, analyzed the pathological specimens according to the Stanford protocol. Both pathologists also determined the surgical approach used based on several criteria pertaining to the pathological specimen.

RESULTS: Overall, 117 patients with a median age of 63 years were included. The main characteristics (i.e., Gleason score, pTNM stage, preoperative PSA and margin) were comparable in both groups (p > 0.05). Pathologists 1 and 2 were able to significantly assess the surgical procedure from the pathological specimen provided (in 76.1 and 69.2 % of cases, respectively). Pathologist 1 had a better performance than pathologist 2 (AUC 0.75, IC 95 % [0.67-0.83] vs. AUC = 0.68 IC 95 % [0.59-0.77]) (p = 0.017). The κ index of the inter-observer agreement was satisfactory (0.76). In a univariate analysis, the criteria linked to the pathologist's assessment were as follows: macroscopic integrity of the specimen (p = 0.04), presence of periprostatic fat (p = 0.04), width of periprostatic tissue (p < 0.001) and nerve-sparing status (p < 0.001).

CONCLUSION: It was possible to determine the surgical procedure from the analysis of the specimen obtained after a radical prostatectomy. In view of these data and from this perspective, one could infer that there are indeed oncological differences between the robotic and open approaches to radical prostatectomy.

Written by:
Drouin SJ, Comperat E, Varinot J, Vaessen C, Bitker MO, Chartier-Kastler E, Mozer P, Shariat SF, Cussenot O, Rouprêt M.   Are you the author?
Service d'Urologie, Hopital Pitié-Salpétrière, AP-HP, 83 Bvd Hopital, 75013, Paris, France.

Reference: World J Urol. 2013 May 31. Epub ahead of print.
doi: 10.1007/s00345-013-1107-2

PubMed Abstract
PMID: 23723015 Prostate Cancer Section