Successful treatment with docetaxel and prednisolone for paxlitaxel and carboplatin-resistant prostate cancer - Abstract

A 60-year-old man was examined at a local clinic for difficulty in urinating, and was diagnosed with prostatic hypertrophy.

He was referred to our department because his prostate-specific antigen (PSA) level was elevated (276 ng/ml). His Gleason score was 4+3, there was one bone metastasis in the left ileac bone, and multiple lung metastases were present. The patient was accordingly diagnosed with stage D2 prostate cancer. Lutenizing hormone-releasing hormone (LH-RH) analogue treatment was initiated in April 1999, and 9 months later the PSA level had decreased to 4.3 ng/ml. Six years and 9 months after the start of hormone therapy, the cancer had developed into castration-resistant prostate cancer and the PSA level had risen to 43.8 ng/ml. Paclitaxel-carboplatin therapy was therefore initiated. Eight months after the start of chemotherapy, the PSA level had decreased to 25.9 ng/ml, but 6 years and 1 month later it had risen to 925 ng/ml, and the chemotherapy was discontinued. Docetaxel-predonine therapy was initiated in March 2012. Three months after the start of chemotherapy, the PSA level had decreased to 3.1 ng/ml, and the bone metastasis was reduced.

Written by:
Kusukawa N, Ishida H, Tanase K, Ito H, Aoki Y, Ooyama N, Akino H, Yokoyama O.   Are you the author?
The Department of Urology, Faculty of Medical Science, University of Fukui.

Reference: Hinyokika Kiyo. 2013 May;59(5):301-4.

PubMed Abstract
PMID: 23719139

Article in Japanese.