AUA 2013 - Session Highlights: Long-term quality-of-life data from CAPSURE for men with localized prostate cancer

SAN DIEGO, CA USA (UroToday.com) - Quality-of-life outcomes often serve as the metric of superiority amongst various therapies in the localized prostate cancer space.

However, data remain sparse regarding late declines in health-related quality of life that results from prostate cancer treatments. In this study, presented at the AUA Meeting in San Diego, researchers from the University of California at San Francisco assessed long-term quality-of-life measures in men with prostate cancer using a longitudinal, nationwide, prostate cancer registry.

The CaPSURE database contains prospectively and longitudinally collected clinical and quality-of-life data in men with prostate cancer since 1995. Encompassing 3 777 men who underwent radical prostatectomy (60%), brachytherapy (20%), external beam radiotherapy (12%), primary androgen deprivation therapy (6%), and active surveillance or watchful waiting (2%), quality of life was assessed using well-validated, self-reported questionnaires. The median follow up for the cohort was over 4 years.

Investigators reported that while quality of life was seen to decline in the first 2 years post-treatment, it then appeared to plateau. Although, radical prostatectomy was slightly inferior in metrics of bother from urinary symptoms than other treatments, these differences were minimal. Meanwhile, radical prostatectomy appeared to have fared slightly better for bowel complaints and mental health. Following the initial plateau, quality of life changed very little from 3 to 10 years post-treatment. This trend was observed consistently over the various other treatment modalities.

Data such as these can help clinicians manage patient expectations over time and help patients select treatment that best fits their risk tolerance. This research was well received, and the poster was awarded best poster in the session.

Abstract Title: Long term health related quality of life outcomes after primary treatment for localized prostate cancer: Results from the CaPSURE registry

Presented by Sanoj Punnen, Janet Cowan, Peter Carroll, and Matthew Cooperberg at the American Urological Association (AUA) Annual Meeting - May 4 - 8, 2013 - San Diego Convention Center - San Diego, California USA

 

Reported for UroToday.com by Anthony T. Corcoran, MD 

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