Course of the type of patient who is candidate for radical prostatectomy over 2 decades (1989-2009) - Abstract

OBJECTIVE: To know the changes that there has experienced the profile of patient candidate to prostatectomía radically throughout last 2 decades in our institution.

MATERIAL AND METHODS: We analyze retrospectively a series of 1.132 patients with prostate cancer stadium T1-T2, submitted to radical prostatectomy during the period 1989-2009. The series divides in five homogeneous groups as for the number of patients and arranged chronologically. There uses the free survival of biochemical progression (SLPB) as criterion principal forecast.

RESULTS: In spite of the changes in the diagnosis and treatment of the disease, from the point of view of the forecast (SLPB) we estimate two groups different from patients: the first 250 controlled ones and the rest. The point of chronological cut places in this series in 1.999. We find significant differences in the majority of the clinical - pathological variables as PSA's level to the diagnosis (P < 0,001), percentage of palpable tumors (P < 0,001), clinical stadium (P < 0,001), Gleason in the prostate biopsy (P =0,004), groups at risk of D'Amico (P < 0,001), pathological stadium (P < 0,001) and percentage of patients mincingly ganglionar (P < 0,001). Nevertheless, there are not detected differences of statistical significance in the Gleason of the specimen of prostatectomy (P =0,06) and in the percentage of surgical margins (P =0,6).

CONCLUSIONS: This study analyzes a patients' wide proceeding sample from the whole Spanish geography and presents some important information that reflect the evolution that has suffered the cancer of prostate located, so much regarding the diagnosis as to the forecast, in our country in the last 20 years.

Written by:
Algarra R, Zudaire J, Rosell D, Robles JE, Berián JM, Pascual I.   Are you the author?
Departamento de Urología, Clínica Universidad de Navarra, Pamplona, España.

Reference: Actas Urol Esp. 2013 Feb 18. pii: S0210-4806(12)00394-4.
doi: 10.1016/j.acuro.2012.09.005

PubMed Abstract
PMID: 23428234

Article in English, Spanish. Prostate Cancer Section