Salvage hormonal therapy against recurrence after curative external beam radiotherapy for locally advanced prostate cancer at Kyoto University Hospital - Abstract

Fifty-three patients with biochemical relapse (BCR) after receiving external beam radiotherapy (EBRT) against locally advanced prostate cancer (stage III : International Union Against Cancer [UICC] 6th edition) between September 1997 and January 2006 at our institution, who were treated with salvage hormonal therapy (HTx), were followed for a mean period of 75.5 months.

There was progression to castrationresistant prostate cancer (CRPC) during the follow-up period in 17 patients (32.0%). The median time to CRPC after initial HTx was 17 months. Univariate analysis revealed that time to BCR after EBRT was significantly associated with progression to CRPC (p=0.022), while PSA-doubling time just before salvage HTx was marginally associated with irradiation dose (p=0. 088, p=0.128 respectively). Multivariate analysis showed that time to BCR after EBRT was the only significant predictor of progression to CRPC (p= 0.035, Hazard ratio ; 0.252, 95% confidence interval ; 0.070-0.905) conclusion, time to BCR after EBRT might be a good predictor for the efficiency of salvage HTx after EBRT against locally advanced prostate cancer.

Written by:
Kato K, Inoue T, Mizowaki T, Kamoto T, Kamba T, Shimizu Y, Norihisa Y, Yamada T, Hiraoka M, Yoshimura K, Ogawa O.   Are you the author?
The Department of Urology, Kyoto University Graduate School of Medicine.

Reference: Hinyokika Kiyo. 2012 Nov;58(11):599-603.

PubMed Abstract
PMID: 23254783

Article in Japanese. Prostate Cancer Section