OBJECTIVE: There is controversial evidence regarding preoperative testosterone (T) levels related to poor prognosis factors after radical prostatectomy (RP).
The aim of this manuscript is to determine the relationship between preoperative T levels and final pathologic report together to biochemical recurrence after RP.
MATERIALS AND METHODS: We prospectively analysed 143 patients submitted to RP from February 2008 to June 2010 in our centre. Pretreatment T and sex hormone-binding globulin levels were determined as part of our clinical protocol. Free calculated (fT) and bioavailable (bioT) T were calculated using Vermeulen's formula. Low T levels were defined as 346ng/dL or less. A comparative analysis with variables pTNM, positive margins, tumour burden, Gleason score, multifocality and biochemical recurrence (using both PSA>0.4ng/dL and PSA>0.2ng/dL as cut-off values) was performed, according to preoperative levels of T.
RESULTS: Variables Gleason score, rate and number of positive margins, tumour burden, tumour multifocality, time to biochemical recurrence and pathological stage were not related to preoperative hormonal levels. Preoperative T< 346ng/dL was not found to be related to PSA recurrence (PSA>0,4ng/dL log-rank, P=.512), although a trend was observed when PSA>0,2ng/dL (log-rank, P=.097).
CONCLUSION: Preoperative T levels were not related to final pathological report or to biochemical recurrence.
Written by:
García-Cruz E, Castañeda-Argáiz R, Carrión A, Alcover J, Sallent A, Leibar-Tamayo A, Romero-Otero J, Alcaraz A. Are you the author?
Departamento de Urología, Hospital Clínic, Barcelona, España.
Reference: Actas Urol Esp. 2012 Dec 12. pii: S0210-4806(12)00349-X.
doi: 10.1016/j.acuro.2012.08.002
PubMed Abstract
PMID: 23246101
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