PURPOSE: To determine the probability of having prostate cancer (PCa) using the combination of serum level of prostate-specific antigen (PSA) and age.
MATERIALS AND METHODS: A total of 160 patients and 190 controls were enrolled in this hospital-based case-control study. Using a logistic regression model and the odds ratio of age and PSA level, the probability of PCa was estimated based on serum level of PSA and age of the participants.
RESULTS: The mean age of patients with PCa and benign prostatic hyperplasia (BPH) was 67.75 ± 8.81 and 62.07 ± 8.71 years, respectively (P < .000). Using univariate analysis, we found that increase in life decades of the cases almost doubles the risk of having PCa (odds ratio = 1.95; P = .00), and the probability of developing cancer may increase by 74% in ketchup consumers. After multiple variable regressions, it was revealed that the odds of developing PCa increase by 90% only for every decade, and other variables did not have any significant association with PCa.
CONCLUSION: In clinical practice, PSA level combined with the age at presentation can be used as predictors of PCa probability and the necessity of biopsy.
Written by:
Pourmand GR, Allameh F, Mohammad K, Dehghani S, Pourmand B, Mehrsai AR, Hosseini SH. Are you the author?
Urology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Reference: Urol J. 2012 Fall;9(4):667-72.
PubMed Abstract
PMID: 23235971
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