Prostate cancer in magnetic resonance imaging: Diagnostic utilities of spectroscopic sequences - Abstract

OBJECTIVE: The aim of our work is to determine the efficacy of a combined study 3 Tesla Magnetic Resonance Imaging (3T MRI), with phased-array coil, for the detection of prostate cancer using magnetic resonance spectroscopy (MRS) and diffusion-weighted images (DWI) in identifying doubt nodules.

SUBJECTS AND METHODS: In this study, we prospectively studied 46 patients who consecutively underwent digital-rectal exploration for high doses of prostate specific antigen (PSA), as well as a MRI examination and a subsequent rectal biopsy. The study of magnetic resonance imaging was performed with a Philips Achieva 3T scanner and phased-array coil. The images were obtained with turbo spin-echo sequences T2-weighted images, T1-weighted before and after the administration of contrast medium, DWI sequences and 3D spectroscopic sequences. The ultrasound-guided prostate biopsy was performed approximately 15 days after the MRI. The data obtained from MR images and spectroscopy were correlated with histological data.

RESULTS: MRI revealed sensitivity and specificity of 88% and 61% respectively and positive predictive value (PPV) of 73%, negative predicted value (NPV) of 81% and accuracy of 76%. In identifying the location of prostate cancer, the sensitivity of 3T MRS was 92%, with a specificity of 89%, PPV of 87%, NPV of 88% and accuracy of 87%; DWI showed a sensitivity of 88%, specificity of 61%, PPV of 73%, NPV of 81% and accuracy of 76%.

CONCLUSIONS: The 3T MR study with phased-array coil and the use of DWI and spectroscopic sequences, in addition to T2-weighted sequences, revealed to be accurate in the diagnosis of prostate cancer and in the identification of nodules to be biopsied. It may be indicated as a resolute way before biopsy in patients with elevated PSA value and can be proposed in the staging and follow-up.

Written by:
Caivano R, Cirillo P, Balestra A, Lotumolo A, Fortunato G, Macarini L, Zandolino A, Vita G, Cammarota A.   Are you the author?
Department of Radiology, I.R.C.C.S. - C.R.O.B., Rionero in Vulture (Pz), Italy.

Reference: J Med Imaging Radiat Oncol. 2012 Dec;56(6):606-16.
doi: 10.1111/j.1754-9485.2012.02449.x

PubMed Abstract
PMID: 23210579 Prostate Cancer Section