There is a need for developing improved therapeutic options for the management of prostate cancer, able to inhibit proliferation of precancerous and malignant lesions and/or to improve the effectiveness of conventional chemopreventive and chemotherapeutic agents.
In this perspective, application of nanotechnology based strategies for the delivery of natural compounds for effective management of the disease is being actively researched. Here, after highlighting the most promising natural compounds for chemoprevention and chemotherapy of prostate cancer, the state of the art nanotherapeutics and the recent proof-of-concept of "nanochemoprevention", as well as the clinical development of promising targeted nanoprototypes for use in the prostate cancer treatment are being discussed.
Sanna V, Siddiqui IA, Sechi M, Mukhtar H. Are you the author?
Department of Dermatology, University of Wisconsin, Madison, WI, USA; Department of Chemistry and Pharmacy, University of Sassari, Italy.
Reference: Cancer Lett. 2012 Nov 29. pii: S0304-3835(12)00695-7.