Fasting blood glucose and lipid profile alterations following twelve-month androgen deprivation therapy in men with prostate cancer - Abstract

Purpose: In this retrospective study, we aimed to investigate the effects of androgen deprivation therapy (ADT) on blood glucose and blood cholesterol levels over a 12-month period.

Materials and Methods: Between January 2010 and June 2012, the data of 44 patients with prostate cancer who were receiving ADT were collected from a hospital database. Patients with additional malignancy or diabetes and those who had been prescribed and were currently taking cholesterol-lowering medication were excluded from the study. Data (including fasting blood glucose levels and a cholesterol profile) were collected and analysed statistically. A P value < 0.05 was considered statistically significant.

Results: Twelve months after the initiation of ADT, fasting blood glucose (FBG), total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglyceride (TG) levels changed. FBG, TC, LDL cholesterol, and TG increased significantly (P = 0.009, 0.000, 0.000, and 0.000, resp.), while HDL cholesterol decreased (P = 0.000).

Conclusion: ADT may increase FBG, TC, LDL cholesterol, and TG but decrease HDL cholesterol by the end of a year of treatment. Therefore, close followup may be needed as a consequence of one-year ADT regarding metabolic alterations.

Written by:
Sağlam HS, Köse O, Kumsar S, Budak S, Adsan O.   Are you the author?
Urology Department, Medical Faculty, Sakarya University, Sakarya, Turkey.

Reference: ScientificWorldJournal. 2012;2012:696329.
doi: 10.1100/2012/696329

PubMed Abstract
PMID: 23125556 Prostate Cancer Section