Development of a new optical device and its feasibility in prostate cancer detection - Abstract

Aim:To develop a new optical device (prostate optical device, POD) for assessment of prostate tissue stiffness and evaluate its sensitivity and specificity in prostate cancer detection.

Patients and Methods:POD was tested in prostate phantoms and in patients with indications for prostate biopsy. Its sensitivity and specificity were compared to digital rectal examination (DRE) and transrectal ultrasonography (TRUS).

Results:POD was able to identify stiffness differences on each prostate phantom. 45 patients were included in the study. Sensitivity of TRUS (40%) was significantly lower to POD (85.7%) and DRE (74.3%) (p = 0.000 and p = 0.003, respectively). There was no statistical difference between POD and DRE (p = 0.221). The combination of POD and DRE showed the highest sensitivity (88.6%), positive predictive value (81.6%), and negative predictive value (42.9%) among all diagnostic tests.

Conclusions: POD identified prostatic stiffness differences with the same sensitivity of DRE performed by an experienced urologist providing an objective indication for prostate biopsy and early prostate cancer detection.

Written by:
Panteliou SD, Tzortzis V, Anagnostopoulos GT, Sunaric MM, Sarris J, Hatzimouratidis K, Hatzichristou D.   Are you the author?
Machine Design Laboratory, Department of Mechanical Engineering and Aeronautics, University of Patras, Patras, Greece.

Reference: Urol Int. 2012 Sep 15. Epub ahead of print.
doi: 10.1159/000339966

PubMed Abstract
PMID: 22986226 Prostate Cancer Section