The distribution of PSA age-specific profiles in healthy Irish men between 20 and 70 - Abstract

Background:Ireland is estimated to have the highest European incidence rate of prostate cancer (Pca) in 2006 which will increase by 275% by 2025.

This study aimed to determine PSA cutoff values in different age groups of healthy male patients without Pca.

Methods:660 men in a pilot men's health programme, aged 18-67, had PSA assayed. Men were grouped into 8 age groups at 5-year intervals: 30-34, 35-39, 40-44, 45-49, 50-54, 55-59, 60-64, and 64-70.

Results:Linear regression demonstrates a PSA velocity of 0.024‚ÄČng/ml/year. The 95% confidence interval demonstrates a near flat line of PSA values from age 20 to 50 and rises after. When transformed logarithmically, PSA correlates highly with expected values from the normal distribution (0.98). A fractional polynomial quantile regression model was used to predict median and 95th percentile for PSA as follows: 30-34 (0.73, 1.57), 35-39 (0.71, 1.65), 40-44 (0.73, 1.85), 45-49 (0.78, 2.17), 50-54 (0.88, 2.63), 55-59 (1.01, 3.25), 60-64 (1.20, 4.02), and 64-70 (1.43, 4.96).

Conclusions: PSA levels are similar to other racial groups but not as high as US Caucasians until 65 years. These data define the predicted PSA for the Irish population and provide a reference for future screening programmes.

Written by:
Casey RG, Hegarty PK, Conroy R, Rea D, Butler MR, Grainger R, McDermott T, Thornhill JA.   Are you the author?
The Adelaide and Meath Hospital-Dublin, Incorporating The National Children's Hospital, Tallaght, Dublin 24, Ireland.

Reference: ISRN Oncol. 2012;2012:832109.
doi: 10.5402/2012/832109

PubMed Abstract
PMID: 22919517 Prostate Cancer Section