This study aims to develop a new agent, the 32P-chromic phosphate-poly(l-lactide) (32P-CP-PLLA) seed and to explore its anticancer effect against prostate cancer (Pca) with local lymphatic metastasis in nude mice.
32P-CP-PLLA seeds of sustained release and nude mouse models of Pca with lymphatic metastasis were prepared. After 4 weeks, the tumor nude mouse models were randomly assigned into five groups. 32P-CP-PLLA seeds (3.7, 7.4, 14.8, and 0 MBq) and 32P-CP (14.8 MBq) were implanted in the tumor tissues of the nude mouse models. The following were discussed in this study: (1) the distributions of 32P-CP-PLLA, (2) the pathological and morphological changes in the tumor and regional lymph nodes, and (3) the changes in white blood cell (WBC) and platelet counts in peripheral blood for toxic reactions. The homemade 32P-CP-PLLA seed was a regular green cylinder, with an even distribution of mass and radioactivity. After implantation, single-photon emission computed tomograph (SPECT) showed that 32P was mainly gathered in the tumor and regional lymph nodes. Morphological examinations revealed that necrosis and hemorrhage were around the tumor and focal lymph nodes. The tumor inhibition rates of the five groups were 70.16%±5.48%, 80.18%±5.84%, 84.97%±4.79%, (-), and 78.81%±3.13%, respectively. These values were all positive when compared with the control group. As a new homemade agent of pure β-ray, local implantation of the agent increased the focal retention of radioactivity at the target. Moreover, effective half-life showed an obvious damage to the tumor and metastatic foci of Pca.
Written by:
He X, Jia R, Xu L, Liang K, Wang Z, Shao G, Huang P, Li W. Are you the author?
Department of Urology, Yangzhou First Hospital Affiliated to Southeast University , Yangzhou, China.
Reference: Cancer Biother Radiopharm. 2012 Jul 26. Epub ahead of print.
doi: 10.1089/cbr.2011.1141
PubMed Abstract
PMID: 22834706
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