Percutaneous MR-guided cryoablation of prostate cancer: Initial experience - Abstract

OBJECTIVE: We report our initial experience and the technical feasibility of transperineal prostate cryoablation under MR guidance.

METHODS: Percutaneous MR-guided cryoablation was performed in 11 patients with prostatic adenocarcinoma contraindicated for surgery (mean age: 72 years, mean Gleason score: 6.45, mean prostate-specific antigen (PSA): 6.21 ng/ml, T1-2c/N0/M0, mean: prostate volume 36.44 ml). Free-hand probe positioning was performed under real-time MR imaging. Four to seven cryoprobes were inserted into the prostate, depending on gland volume. The ice ball was monitored using real-time and high-resolution BLADE multi-planar imaging. Patients were followed at 1, 3, 6, 9 and 12 months after the procedure with serum PSA level and post-ablation MRI.

RESULTS: Prostate cryoablation was technically feasible in 10/11 patients. The ice ball was clearly and sharply visualised in all cases as a signal-void area. Mean ice-ball volume was 53.3 ml. Mean follow-up was 15 months (range: 1-25). Mean PSA nadir was 0.33 ng/ml (range: 0.02-0.94 ng/ml). Mean hospitalisation was 5 days (range: 3-13). Complications included a urethro-rectal fistula, urinary infection, transient dysuria and scrotal pain.

CONCLUSIONS: MR-guided prostate cryoablation is feasible and promising, with excellent monitoring of the ice ball. Future perspectives could include the use of MR guidance for focal prostate cancer cryotherapy.

Written by:
Gangi A, Tsoumakidou G, Abdelli O, Buy X, de Mathelin M, Jacqmin D, Lang H.   Are you the author?
Department of Interventional Radiology, University Hospital of Strasbourg, 1 Place de l'Hôpital, 67091, Strasbourg, France.

Reference: Eur Radiol. 2012 Aug;22(8):1829-35.
doi: 10.1007/s00330-012-2411-8

PubMed Abstract
PMID: 22752525 Prostate Cancer Section