Docetaxel-induced fatal interstitial pneumonitis in a patient with castration-resistant prostate cancer - Abstract

A 69-year-old man with castration-resistant prostate cancer (CRPC) received docetaxel and a corticosteroid. After the third cycle of docetaxel administration, he presented with dyspnea, cough, sputum, and fever of 39.2℃. The chest X-ray and chest computed tomography (CT) revealed a diffuse reticulonodular shadow in both lungs, which suggested interstitial pneumonitis. Initially, we used empiric broad-spectrum antibiotics and high-dose corticosteroids. However, his condition progressively became worse and he was transferred to the intensive care unit, intubated, and placed on mechanical ventilation. He died 4 days after hospital admission. Here we report this case of fatal interstitial pneumonitis after treatment with docetaxel for CRPC. We briefly consider docetaxel-induced pneumonitis to make physicians aware of the possibility of pulmonary toxicity so that appropriate treatment can be begun as soon as possible.

Written by:
Min BD, Kang HW, Kim WT, Kim YJ, Yun SJ, Lee SC, Kim WJ   Are you the author?
Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea

Reference: Korean J Urol. 2012 May;53(5):371-4
doi: 10.4111/kju.2012.53.5.371

PubMed Abstract
PMID: 22670199