Androgen deprivation therapy for prostate cancer does not increase cardiovascular mortality in the long term - Abstract

Objective:To determine if 6 months of neo-adjuvant androgen deprivation is associated with the long-term risk of cardiac mortality.

Methods: In the TROG 96.01 trial, 802 men with locally advanced prostate cancer were randomized to radiotherapy either alone or with 3 or 6 months of neo-adjuvant androgen deprivation therapy (NADT). Competing risk methodology was used to derive the cumulative incidence of fatal cardiac events.

Results: At 10 years, the cumulative incidence of fatal cardiac events for the radiation therapy alone arm was 7.54% compared to a nonstatistically significant decreased incidence of 6.44% in the 6-month NADT arm (p = 0.65). Men aged over 65 years were not at an increased risk. Additional androgen deprivation therapy given as secondary treatment at tumor progression did not confer an increased risk.

Conclusion: These data suggest that fatal cardiac events are not more common in men receiving up to 6 months of NADT.

Written by:
Wilcox C, Kautto A, Steigler A, Denham JW. Are you the author?
School of Medicine and Public Health, The University of Newcastle, Callaghan, N.S.W., Australia.

Reference: Oncology. 2012;82(1):56-8.
doi: 10.1159/000334999

PubMed Abstract
PMID: 22310055