The emerging role of diffusion-weighted MRI in prostate cancer management - Abstract

A significant amount of research has focused on the role of diffusion-weighted MRI (DW-MRI) in the management of patients with prostate cancer. Although uncertainties remain, a clearer picture of where this technique fits into clinical practice is now available. A combination of DW-MRI and T2-weighted MRI (T2W-MRI) demonstrates improved accuracy for lesion detection and localization compared with T2W-MRI alone, and has been suggested as a tool to guide tissue biopsy. DW-MRI could also have roles in active surveillance, evaluating treatment efficacy, and predicting disease recurrence. Furthermore, DW-MRI offers the exciting possibility of gathering information about tumor characteristics and aggressiveness in a noninvasive manner. Validation in large prospective multicenter trials is critical if this technique is to be integrated into current management algorithms for prostate cancer.


Written by:
Lawrence EM, Gnanapragasam VJ, Priest AN, Sala E.   Are you the author?
Department of Radiology, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge CB2 1QQ, UK.

Reference: Nat Rev Urol. 2012 Jan 17. Epub ahead of print.
doi: 10.1038/nrurol.2011.222

PubMed Abstract
PMID: 22249194 Prostate Cancer Section