The relationship between obesity and prostate cancer risk has been studied extensively but with inconsistent findings, particularly for tumour aggressiveness. Few studies have investigated weight change and prostate cancer incidence or mortality. Using the Melbourne Collaborative Cohort Study, which recruited 17,045 men aged between 40 to 69 years at study entry, we investigated associations between reported weight and BMI at age 18 years and measured at study entry, height, weight change between age 18 years and study entry and prostate cancer incidence and mortality. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox regression. During follow up (mean 15 years) of 16,514 men, we ascertained 1,374 incident prostate cancers, of which 410 were classified as aggressive, and 139 deaths from prostate cancer. The incidence of all prostate cancer was not associated with body size or weight change. Weight and BMI at study entry were positively associated with aggressive prostate cancer risk (HR=1.06, 95% CI:1.00-1.13, per 5 kg; HR=1.27, 95% CI:1.08-1.49 per 5kg/m2 ) and prostate cancer mortality (HR=1.12, 95% CI:1.01-1.23, per 5 kg; HR=1.49, 95% CI:1.11-2.00, per 5kg/m2 ). Weight gain was positively associated with prostate cancer mortality (HR 1.13, 95% CI:1.02-1.26 per 5kg increment); the HR for ≥20 kg weight gain between age 18 and study entry compared with < 5 kg gain over this period was 1.84, 95% CI:1.09-3.09. Higher adult weight and BMI increases the risk of aggressive prostate cancer and mortality from prostate cancer. Weight gain during adult life is associated with increased prostate cancer mortality.
Bassett JK, Severi G, Baglietto L, Macinnis RJ, Hoang HN, Hopper JL, English DR, Giles GG. Are you the author?
Cancer Epidemiology Centre, Cancer Council Victoria, 1 Rathdowne Street, Carlton South, Victoria 3053, Australia.
Reference: Int J Cancer. 2011 Dec 31. Epub ahead of print.
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