Department of Medicine Austin Health/Northern Health, University of Melbourne, Studley Road, Heidelberg, Victoria 3084, Australia.
Department of Endocrinology, Austin Health, Studley Road, Heidelberg, Victoria 3084, Australia.
Androgen deprivation therapy (ADT) is a major component of the contemporary management of prostate cancer. ADT's use is increasing rapidly. The side effects of this therapy include loss of bone mass and fractures, increase in fat mass, and worsening of insulin resistance, the metabolic syndrome, diabetes and cardiovascular risk, and anemia and loss of muscle. Neuropsychological and sexual symptoms are common. The impact of these side effects is often overlooked or underestimated in decisions about prostate cancer therapy. This review surveys the data relating to the side effects of ADT and provides recommendations regarding their minimization and management.
Written by:
Grossmann M, Zajac JD. Are you the author?
Reference: Endocrinol Metab Clin North Am. 2011 Sep;40(3):655-71.
doi: 10.1016/j.ecl.2011.05.004
PubMed Abstract
PMID: 21889727
UroToday.com Prostate Cancer Section
